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Ben Shelton retired from the US Open due to a shoulder injury, ending his run in the third round. Frances Tiafoe also exited early, leaving Taylor Fritz as the last American hope, intensifying the pressure on him.

Aryna Sabalenka commenced her US Open title defence successfully, while Novak Djokovic progressed towards a potential record 25th Grand Slam. Alexandra Eala made history for the Philippines, and Indonesia's Janice Tjen also secured a notable win. Emma Raducanu marked her return with a victory, while Daniil Medvedev faced an unexpected early exit.